一、基本信息
张成，副教授，博导
电子邮件：zhangcheng1988@hubu.edu.cn
研究方向：
1. 智能型纳米药物载体的设计与制备。
2. 基于细菌微生物为平台的肿瘤精准治疗研究。
二、教育背景
2016.9-2019.12 武汉大学 化学与分子科学学院 高分子化学与物理 理学博士
2012.9-2015.6 威廉希尔中国官网 材料科学与工程学院 材料学 工学硕士
2008.9-2012.6 威廉希尔中国官网 材料科学与工程学院 高分子材料与工程 工学学士
三、工作经历
2019.12–至今 威廉希尔中国官网生科院 博士后，副教授
四、科研项目
1. 湖北省科学技术协会科普提能项目，2025/01-2025/12，在研，主持
2. 肿瘤细菌疫苗研发，2024/11-2026/11，在研，主持
3. 重组胶原蛋白的高效表达，2024/10-2026/10，在研，主持
4. 国家自然科学青年基金，2024/01-2026/12，在研，主持
5. “楚天学子”计划人才配套启动经费，2021/06-2026/06，在研，主持
6. 威廉希尔中国官网青年基金，2022/01-2023/12，结题，主持
7. 中国博士后科学基金面上资助，2021/01-2022/12，结题，主持
8. 省部共建生物催化与酶工程国家重点实验室开放课题资助，2021/12-2023/12，结题，主持
五、代表著作（#共同一作，*通讯作者）
l He, S.; Zhao, S.; Luo, X.; Liu, N.; Zhang, Y.; Wang, S.; Yang, Y.*; Ma, L.*; Zhang, C.* Intelligent Bacterial Platform Induces Programmed Death-Ligand 1 Lysosomal Degradation to Enhance Antitumor Immunity. International Journal of Biological Macromolecules 2025.
l Chen, L.; Li, Y.; Zhang, X.; Ma, L.*; Zhang, C.*; Chen, H.* A One-Two Punch of Inflammation and Oxidative Stress Promotes Revascularization for Diabetic Foot Ulcers. Materials Today Bio 2025.
l Ge, D.; Ren, D.; Duan, Y.; Luo, X.; He, S.; Qin, W.; Wang, F.; Yin, W.; Ma, L.*; Yang, Y.*; Zhang, C.* Hollow MnO2-Based Multifunctional Nanoplatform for Enhanced Tumor Chemodynamic Therapy. Sci. China Mater. 2025.
l Cai, M.; Luo, J.; Yang, C.; Yang, X.; Zhang, C.*; Ma, L.*; Cheng, Y.* ABHD12 Contributes to Tumorigenesis and Sorafenib Resistance by Preventing Ferroptosis in Hepatocellular Carcinoma. iScience 2023.
l Xu, W.; Chen, H.; Duan, Y.; Ge, D.; Ren, D.; Zhao, S.; Liu, Y.; Ma, L.;* Zhang, C.* Bacterial Expression of Promelittin for Safe and Effective Tumor Therapy. ACS Applied Materials & Interfaces 2023.
l Ren, D.; Cheng, Y.; Xu, W.; Qin, W.; Hao, T.; Wang, F.; Hu, Y.; Ma, L.;* Zhang, C.* Copper-Based Metal-Organic Framework Induces NO Generation for Synergistic Tumor Therapy and Antimetastasis Activity. Small 2023.
l Qin, W.; Xu, W.; Wang, L.; Ren, D.; Cheng, Y.; Song, W.; Jiang, T.; Ma, L.;* Zhang, C.* Bacteria-Elicited Specific Thrombosis Utilizing Acid-Induced Cytolysin A Expression to Enable Potent Tumor Therapy. Advanced Science 2022.
l Wang, L.; Qin, W.; Xu, W.; Huang, F.; Xie, X.; Wang, F.; Ma, L.*; Zhang, C.* Bacteria-Mediated Tumor Therapy via Photothermally-Programmed Cytolysin A Expression. Small 2021.
l Qin, W.; Wu, Y.; Hu, Y.; Dong, Y.; Hao, T.; Zhang, C.* TPE-Based Peptide Micelles for Targeted Tumor Therapy and Apoptosis Monitoring. ACS Applied Bio Materials 2021.
l Zhang, C.; Qin, W. J.; Bai, X. F.; Zhang, X. Z. Nanomaterials to Relieve Tumor Hypoxia for Enhanced Photodynamic Therapy. Nano Today 2020.
l Zhang, C.; Peng, S. Y.; Hong, S.; et al. Biomimetic Carbon Monoxide Nanogenerator Ameliorates Streptozotocin Induced Type 1 Diabetes in Mice. Biomaterials 2020.
l Wang, S. B; Zhang, C.#; et al. Near-infrared Light Responsive Nanoreactor for Simultaneous Photothermal and Anti-Inflammation Therapy of Tumor. ACS Central Science 2020.
l Zhang, C.; et al. ZIF-8 Integrated With Glucose Oxidase for Glucose-Responsive Insulin Delivery. Journal of Controlled Release 2020.
l Zhang, C.; Liu, W. L.; Bai, X. F.; et al. A Hybrid Nanomaterial With NIR-Induced Heat and Associated Hydroxyl Radical Generation for Synergistic Tumor Therapy. Biomaterials 2019.
l Zhang, C.; Zheng, D. W.; Li, C. X.; et al. Hydrogen gas Improves Photothermal Therapy of Tumor and Restrains the Relapse of Distant Dormant Tumor. Biomaterials 2019.
l Zhang, C.; Wang, S. B.; Chen, Z. X.; et al. A Tungsten Nitride-Based Degradable Nanoplatform for Dual-Modal Image-Guided Combinatorial Chemo-Photothermal Therapy of Tumors. Nanoscale 2019.
l Wang, S. B.; Zhang, C.#; Chen, Z. X.; et al. A Versatile Carbon Monoxide Nanogenerator for Enhanced Tumor Therapy and Anti-Inflammation. ACS Nano 2019.
l Wang, S. B; Zhang, C#.; Liu, X. H; et al. A Tungsten Nitride-Based O2 Self-Sufficient Nanoplatform for Enhanced Photodynamic Therapy Against Hypoxic Tumors. Advanced Therapeutics. 2019.
l 专利名称：一种智能工程细菌系统及其制备和在抗肿瘤药物中的应用。发明人：张成;马立新;许文轩;任德宝。专利号：ZL 202211274492.4
六、获奖
· 湖北省博士后优秀人才跟踪支持计划入选者
· 湖北省“楚天学者计划”楚天学子
七、招生要求
热切欢迎志在科研、具有良好英语功底学子加入我组。饱蘸三五春秋，不负韶华，携手开创广阔天地！！
